Once relegated to treating conditions such as nasal congestion and rhinitis, intranasal drug
delivery is now gaining attention for administration of a wide range of pharmaceuticals.
Advantages of intranasal drug delivery include:
- Large nasal mucosal surface area for dose absorption
- Rapid drug absorption via highly-vascularized mucosa
- Rapid onset of action
- Ease of administration, non-invasive
- Avoidance of the gastrointestinal tract and first-pass metabolism
- Improved bioavailability
- Lower dose/reduced side effects
- Minimal aftertaste
- Improved convenience and compliance
- Self-administration
- New patent coverage for drug formulations about to expire
Although traditional nasal drug delivery methods offer significant advantages over
injection or oral administration, they face challenges that limit efficacy and
applications.
Spray Bottle and Nebulizer Limitations
